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Upon receipt of a normal diet containing no more than 30% fat, Staxyn pharmacokinetic parameters (Cmax, Tmax, AUC) are not changed. Based on these data can be assigned to Staxyn independent meal.

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After twenty minutes after administration, the corpus cavernosum smooth muscle is relaxed by improving blood flow to the genitals. This creates ideal conditions for natural prolonged erection necessary for full sexual intercourse.

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Early treatment recommended dose is 10 mg (approximately 25-60 minutes before sexual activity). The maximum dose recommended dose is 10 mg 1 time a day. In order to ensure an adequate response to treatment requires sexual stimulation. The drug Staxyn® OTD efficacy of receipt for 4-5 hours before sexual intercourse. adjustment in the elderly (over 65 years) is not required. In patients with mild renal impairment (class A on a scale Child-Pugh) converts dosing is required.

It is not recommended for use Staxyn® OTD in patients with moderate hepatic impairment (class B on a scale of Child-Pugh). delivery mode change is required in patients with mild (CC> 50-80 ml / min), moderate (QA> 30-50 ml / min) and severe (creatinine clearance <30 mL / min) renal impairment. Staxyn evidence of erectile dysfunction (inability to achieve and maintain an erection necessary for sexual intercourse).

Not suitable for simultaneous reception of nitrates in angina increased sensitivity to the drug Staxyn. Contraindications Hypersensitivity to any component of the drug; concurrent application of nitrates or drugs, which are the production of nitric oxide donators; simultaneous application of the active or moderately potent inhibitors of CYP3A4, such as ketoconazole, ritonavir, indinavir, erythromycin and clarithromycin; drugs to treat erectile dysfunction, should not be used in men, which is not shown sex (eg, patients with underlying heart disease such as unstable angina or acute heart failure (class III or IV according to the classification of New York Heart Association).

Adverse action catching and parasitic diseases: rare - conjunctivitis violations of the immune system: infrequent - angioedema and angioedema rarely.

- allergic Mental disorders: infrequent - sleep disorders of the nervous system: very often - headache, often - dizziness, rarely - paresthesia and dysesthesia, drowsiness, rarely -obmorok, memory loss, seizures violations of organ glance ... rarely - blurred vision, redness of the conjunctiva of the eye, impaired color vision, pain in the eyeballs and discomfort in the eyes, photophobia, rarely - increased intraocular pressure. fragments of the organ of hearing and labyrinth disorders: rarely - ringing in the ears, dizziness. Violation of the heart: rare - palpitation, tachycardia; rarely - angina, myocardial infarction, ventricular tachycardia interference. Fragments of vessels: often - vasodilation; rarely - hypotension. Breaking respiratory organs, thoracic and mediastinal disorders: often - nasal congestion; rarely - shortness of breath, nasal sinuses.

Violations of the gastrointestinal tract, often -dispepsiya; rarely - nausea, abdominal pain, diarrhea, gastro-esophageal reflux disease, gastritis, vomiting. Violation of the liver and biliary tract: rarely - increased activity of transaminases. Violation of the skin and subcutaneous tissue disorders: rarely - erythema, rash. Violations of the musculoskeletal and connective tissue disorders: rarely - back pain, increased CPK, increased muscle tension and spasm, muscle pain.

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The maximum dose recommended dose is 20 mg 1 time a day.

Fragments of the genitals and breasts: rare - increased erections; rarely - priapism. General disorders and injection site: infrequent - distress; rarely - pain in the chest.

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Product form and composition tablets active substance Staxyn 5 mg, 10 mg or 20 mg; Excipients: Crospovidone - 4.35 / 6.25 / 8.85 mg; magnesium stearate - 0.87 / 1.25 / 1.77 mg; MCC - 74.419 / 105.023 / 141.797 mg; Colloidal silica - 0.435 / 0.625 / 3.385 mg; Sheath Film: Macrogol 400-0,555 / 0.797 / 1.128 mg; Hypromellose - 1.664 / 2.391 / 3.385 mg; titanium dioxide - 0.455 / 0.653 / 0.925 mg; dye Yellow iron oxide - 0.092 / 0.133 / 0.188 mg; colorant Iron oxide red - 0.007 / 0.011 / 0.015 mg; The package 1 and 4 pcs. Disintegrating tablet Active ingredient: Staxyn hydrochloride trihydrate (micronized) 11 852 mg equivalent to 10 mg of Staxyn material; Excipients: aspartame - 1.8 mg, flavor, peppermint (acacia gum, maltodextrin, menthol, oil of peppermint leaves, oil field mint leaves) - 2.7 mg Magnesium stearate - 4.5 mg, cargo bristles ( "Pharma Burst ™") ( crospovidone, mannitol, colloidal silicon dioxide, sorbitol) - 159.15 mg;

The package 1, 2, and 4 pcs. A special message for the diagnosis of erectile dysfunction is necessary to conduct a thorough investigation.

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With long-term and regular use of funds at the man marked improvement in blood circulation, normal hormone levels, enhance immunity. Moreover, Staxyn possesses strong anti-inflammatory action, so can resist the development of inflammatory processes penis.

The maximum recommended dose frequency of administration of the preparation - 1 time per day. Depending on the efficacy and tolerability of treatment dose can be increased to 20 mg or decreased to 5 mg per day.

Under the effects an increase of the penis, increase sexual potency, endurance and muscle tone. Action items aimed at reproductive work, but at the same time have a positive effect on the body as a whole.

Dmitriy02 February 2017 00:00

Staxyn does improve erection works by increasing genital blood flow. Staxyn active ingredients have a relaxing effect not only on the muscles in the penis, and arterial blood. As a result, blood flow to the penis, allowing you to quickly achieve a strong erection.

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Staxyn dose should not exceed 5 mg when administered with erythromycin, ketoconazole, itraconazole. The dose of ketoconazole and itraconazole thus should not exceed 200 mg. The combination of ritonavir and indinavir.

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Staxyn action begins 20-30 minutes after administration and can last up to 36 hours. The drug can take courses for maximum effect. Staxyn is not medium. Its action takes place through natural sexual stimulation.

Concomitant use of nitrates or drugs, which are nitric oxide donators.

Accepted for 25-60 minutes before sexual intercourse.

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The drug should be taken twenty minutes before sexual intimacy in a dosage which does not exceed 20 mg per day. After sixty-five years, experts recommend taking 5 mg general, the average dose is 10 mg.

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Profile selectivity for PDE M1 is similar to Staxyn; in vitro ability to inhibit PDE-5 is 28% compared to Staxyn, corresponding to 7% efficacy. Termination. The total clearance of Staxyn is 56 l / h, the final T1 / 2 - about 4-5 hours. After administration of Staxyn metabolites excreted primarily in the gastrointestinal tract (91-95% of the dose), to a lesser extent oral - kidneys (2-6% of the dose). Elderly patients. In healthy elderly males (65 years) compared to younger subjects (=45 years) hepatic clearance of Staxyn was reduced.

The average AUC in the elderly increased by 52%. Patients aged 65 years or older when they get oral dispersible tablet (10 mg) was an increase in AUC of between 31 and 39% and Cmax from 16 to 21% compared to patients aged 45 years or younger. When receiving a dispersible tablet in the mouth (10 mg) in patients within 10 days of age to 45 years and 65 years and older were observed in plasma collection area Staxyn.

However, the difference in efficacy and safety in elderly and young patients are not checked. Renal impairment. Patients with mild (creatinine Cl - 55-80 ml / min) and moderate (Clkreatinina - 30-50 ml / min), the degree of renal function Staxyn pharmacokinetic parameters are comparable to healthy people. In severe renal impairment (creatinine Cl <30 ml / min) mean AUC value index is increased by 21% and Cmax decreased by 23%. A significant correlation between creatinine clearance and Staxyn plasma levels (AUC and Cmax) is not observed. In hemodialysis patients, the pharmacokinetics of Staxyn has not been studied. Abnormal liver function.

In patients with mild to moderate renal impairment Staxyn clearance activity is reduced in proportion to the level of liver dysfunction. In mild hepatic failure (step A by Child-Pugh) a significant increase in Cmax and AUC figures 1.2 times (AUC - 17%, Cmax - 22%), while moderate (level BI according to Child Pugh) - 2.6 (160%) and 2.3 (130%) times, respectively, compared to healthy volunteers. Patients with severe renal impairment (step B of Child-Pugh) Staxyn pharmacokinetics not studied.

Nitrates, nitric oxide donator: Combined project Staxyn and nitrates is contraindicated because of the risk of hypotension.

Abnormal and rare (0.1-1%), swelling of the face, photosensitivity, pain, hypertension, change of functional "liver" tests, increased GGT, increased levels of creatine kinase, myalgia, drowsiness, shortness of breath, blurred vision, discharge eyes, priapism, anaphylactic reactions (including laryngeal edema), angina, arterial hypotension, myocardial ischemia, orthostatic hypotension, syncope, increased muscle tension, epistaxis, glaucoma.

Staxyn duration of action is 4-5 hours.

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